
Yet another study on food & health.
Looking at the impact of sugar in food and beverages.
Sugar is a much beloved sweetener. Craved like a lovers touch by most biological beings that dare to ever look into the abyss and allow its tastebuds to grace this natural force of addiction.
But as much as all things living seemingly enjoy the taste of sugar and more modern artificial sweeteners. Scientifically speaking the bad health impact of sugar ( from obesity to diabetes and cancer risk, poor dental health and non existing nutritional value ) and other sweeteners have thankfully turned countless of humans into die hard "no sugar" please sentinels. So let us take a brief look at a brand new 2019 study and let us find out if this study too will add even more reasons to say no to sugar and other sweeteners in your food and beverages.
Obesity all on its own actually increases an individual's risk of developing many types of cancer, including colorectal cancer.
And one of the many factors driving the global rise in obesity rates is thought to be the use of sugar and modern sweeteners like high-fructose corn syrup (HFCS) as a sweetener in food and beverages.
This particular study which we will be talking about today found that consumption of HFCS promotes an increased growth of intestinal cancer even in the absence of obesity in mice. Apparently, an enzyme in tumors (ketohexokinase) is responsible for responding to the consumption of sugar and other sweeteners such as high-fructose corn syrup as a signal to alter tumor cell metabolism.
A biological response which in turn leads to enhanced cell growth.
2050AD, the ugliness of humanity.
[ Oceans run the risk of having more total weight of plastic than fish.]

What remains to be seen, however, is if this will apply to actual human beings too. Because animal-based studies do not always translate to the same outcome in humans.
All things considered, however, when we look at everything we already know about sugar and the physical impact and response in humans and other animals, it will for good reason, turn out to be a zero surprise if this mouse based study does turn out to be a good representation of the biological response in homo sapiens and other Hominidae too.
So let us take a short look at the scientific backstory to this study.
We already know that increased consumption of sugar-based food and beverages (SSBs) (and other unhealthy modern day choices such as fast food and sedentary living )has been going hand in hand with an epidemic increase of obesity, diabetes and some cancer types around the world.
During this time period, colorectal cancer (CRC) have also seen a worldwide increase in both young and middle-aged humans. Meanwhile, plenty of studies have shown that excessive consumption of sweetened food and beverages do cause obesity, and that being obese increases the risk of colorectal cancer all by itself, along with a clear increase in other bad health factors.
Two important factors are obesity and metabolic syndrome.
Both of whom indirectly affect tumor development by changing a myriad of physical factors and the entire endocrine system. In short, the healthier and more fit you are, the better your body is when it comes to keeping healthy and cancer free, as well as putting 100% of the nutrition you consume on a daily basis to a proper, health and fitness improving use.
And likewise, the more overweight you are, and the more body fat mass you carry around, the worse your body becomes at staying healthy and maintaining its various hormonal and physical systems.
Actually creating a self-fulfilling chain where the more obese and sedentary you are, the worse your body becomes at using the nutrition you eat in a healthy way. Storing more fat and enlarging individual fat cells, and lowering your actual daily calorie need. all while using less nutrition for recovery, repair and the maintenance of your actual capacity to perform physical activities.
Creating a poor insulin response as well as altering our biological hormone production to something less functional et cetera.
But this study zoned in on nothing but the biological impact of sugar and artificial sweetener consumption amongst its rat participants.
The outcome?.
The consumption of HFCS in the drinking water during this study led to a clear increase in obesity in the participating mice. Further, it also leads to metabolic dysfunction over an 8-week period.
But, the main objective of this study (and article) was the possibility of intestinal tumor growth, in other words, cancer. So how about that?.
In this study, the consumption of sugar and artificial sweeteners significantly increased the number of large adenomas (>3 mm in diameter) and high-grade tumors in the sugar and sweetener group. The results suggest that a perpetual intake of sugar and sweeteners increase intestinal cancer tumor growth regardless of obesity and the prevalence of metabolic syndrome.
Quote
"We next explored the mechanism by which increased glycolysis enhances tumor growth in HFCS-treated APC−/− mice. In addition to generating ATP, glycolysis serves as a carbon source for de novo fatty acid synthesis. Cancer cells rely heavily on fatty acid synthesis (also known as “de novo lipogenesis”) for cellular membrane formation, energy generation and storage, and intracellular signaling (29, 30). Using next-generation RNA sequencing (RNA-seq), we found that the expression levels of all lipogenic enzymes, including acetyl-CoA (coenzyme A) carboxylase alpha (ACACA) and fatty acid synthase (FASN), were markedly increased in APC−/− tumors in comparison to IECs (Fig. 3A and fig. S7A). Accordingly, APC−/− tumors had an increased abundance of long-chain fatty acids, as measured by a LC-MS/MS analysis (fig. S7B), and demonstrated increased incorporation of 14C-glucose into intracellular lipids as compared to the IECs following an oral bolus of HFCS (radiolabeled 14C-glucose together with unlabeled fructose) (fig. S7C).
"
So in other words.
This study is one more reason to avoid the consumption of added sugar and artificial sweeteners in food and beverages
But, the takeaway should absolutely not be that quality carbs from plant-based foods, such as fruits and berries are bad. We are talking about the addition of sugar and artificial sweeteners in food and drinks, not the natural quality carbs and fibers you will naturally find in fruit and berries, veggies and other greens.
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As long as we still have a functional world, I´ll be out there, grinding it out in the gym, lifting heavy as fuck weights. Eating healthy vegetarian food and enjoying nature and wildlife, while I marvel at the beauty of Scandinavia and "höga kusten" right here in Sweden as I produce gorgeous Nordic fine art products, complete with our ancient Viking soul and Scandinavian natures uniquely calm and quiet wild charm.
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Because no matter how advanced your society is, no matter how sustainable and healthy it is, no matter how far ahead of the global curve your society might be, we all can do much more. We all need to do much more. Because even the best of societies on this planet are still so far from achieving the healthy kind of society we all need to create.
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The study.
And the study itself, sugar & sweetners and intestinal tumor growth.
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